This cross-sectional positron emission tomography study describes an overactive presynaptic serotonin system, with increased serotonin synthesis and transporter availability, in patients with social anxiety disorder.
This randomized clinical trial investigates the preliminary finding that the sweet-liking phenotype interacts with a high level of craving for alcohol to improve the response to naltrexone in patients with alcohol dependence.
This randomized clinical trial explores whether dynamic psychotherapy is not inferior to cognitive therapy in the treatment of major depressive disorder among adults treated in a community mental health center.
This randomized clinical trial tests whether whole-body hyperthermia has specific antidepressant effects when compared with a sham treatment.
This case-control study examines whether the pattern of brain connectivity across striatal subregions is abnormal in unmedicated patients with schizophrenia and whether this abnormality relates to psychotic symptoms and extrastriatal dopaminergic transmission.
This randomized clinical trial evaluates the use of N-acetylcysteine in short-term treatment of skin-picking disorder.
This review article summarizes what is known about the effects of cannabis use on human behavior, including cognition, motivation, and psychosis.
This Viewpoint discusses the potential benefits and risks associated with mental health–related mobile apps.
This randomized clinical trial compares the efficacy of light treatment, both as monotherapy and in combination with fluoxetine, with a sham placebo condition for adults with nonseasonal major depressive disorder.
This placebo trial examines the neurochemical mechanisms underlying the formation of placebo effects in patients with major depressive disorder.
This study compares the effectiveness of sertraline vs placebo in a sample of women with premenstrual dysphoric disorder.
This cross-sectional study reports that medication-free patients with major depressive disorder vs bipolar disorder appear to differ in brain activations during emotion regulation, both while depressed and in remission.