This randomized clinical trial evaluates the safety and efficacy of basimglurant modified-release vs placebo as adjunctive therapy to ongoing antidepressant medication therapy in patients with major depressive disorder who had inadequate response within the current episode.
This placebo trial examines the neurochemical mechanisms underlying the formation of placebo effects in patients with major depressive disorder.
This meta-analysis shows that various reporting biases are present for trials on the efficacy of US Food and Drug Administration–approved second-generation antidepressants for anxiety disorders.
This case-control study examines whether mortality increases in elderly patients with dementia who receive antipsychotic medications.
This Viewpoint briefly reviews evidence on the range of antidepressant choices needed for depression treatment, examines current antidepressant use patterns in Part D, and assesses how the proposed change would affect the quality of antidepressant treatment in Medicare.
This meta-analysis supports a proof-of-concept concerning use of anti-inflammatory treatment in depression.
Blumenthal and colleagues estimate weight gain associated with specific antidepressants over the 12 months following initial prescription in a large and diverse clinical population.
In a longitudinal, prospective cohort study of 2654 women who were recruited before 17 completed weeks of pregnancy, Yonkers and coauthors determine whether a likely diagnosis of posttraumatic stress disorder or antidepressant and benzodiazepine treatment during pregnancy is associated with risk of preterm birth.
Castrén describes the network hypothesis of antidepressant action that proposes that
recovery from depression and related mood disorders is a gradual process that develops slowly and is
facilitated by structured guidance and rehabilitation.