This epigenetic association study investigates whether aberrant DNA methylation contributes to circuit- and diagnosis-specific abnormal expression of GAD1 regulatory network genes in schizophrenia and bipolar disorder.
This study assesses dendritic spine loss in the dorsolateral prefrontal cortex in individuals with schizophrenia and individuals with bipolar disorder and suggests that the 2 disorders may share some common pathophysiological features.
To test the hypothesis that neurodegeneration and neuronal density in brainstem aminergic nuclei are related to late-life depression, Wilson et al performed a clinicopathological cohort study among 124 older persons without dementia who had annual evaluations (with self-report of depressive symptoms), died, and underwent a postmortem neuropathological examination.
Blasi et al examine the functional effects of the serotonin receptor 2a (5-HT2AR) gene on 5-HT2AR
messenger RNA and protein expression, on prefrontal phenotypes linked with genetic risk for
schizophrenia, and on treatment with olanzapine.