This genome-wide association study assesses analyses from 3 studies of substance use disorder genetics to identify DSM-IV criteria for cannabis dependence in a large African American and European American cohort.
Choong et al for the ODEX team determine whether polymorphisms within CRTC1 are associated with adiposity markers in psychiatric patients and the general population.
Lautner et al evaluate whether the apolipoprotein E genotype affects the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease (AD) and whether the association of the ε4 allele with biomarkers depends on cortical β-amyloid status.
Tao et al characterize ZNF804A expression in human brain and investigate how it changes across the life span and how it is affected by rs1344706, schizophrenia, bipolar disorder, and major depressive disorder.
Dima et al determine whether genetic risk for bipolar disorder associated with CACNA1C rs1006737 and ANK3 rs10994336 is mediated through changes in regional activation and interregional connectivity of the facial affect–processing network.
Blasi et al examine the functional effects of the serotonin receptor 2a (5-HT2AR) gene on 5-HT2AR
messenger RNA and protein expression, on prefrontal phenotypes linked with genetic risk for
schizophrenia, and on treatment with olanzapine.