Hampton et al estimate the numbers and rates of adverse drug event emergency department visits involving psychiatric medications among US adults between 2009 and 2011. Medical records from national probability samples were reviewed and analyzed. Exposures were antidepressants, antipsychotics, lithium salts, sedatives and anxiolytics, and stimulants.
This nationwide cohort study investigates whether the use of hormonal contraception is positively associated with subsequent use of antidepressants and a diagnosis of depression among women in Denmark.
This randomized clinical trial compares the effects of adjunctive raloxifene with antipsychotic therapy vs antipsychotics alone on illness severity in women with refractory schizophrenia.
This pharmacoepidemiology study examines associations between first-trimester antipsychotic exposure and risk for overall congenital and cardiac malformations among children born to women enrolled in Medicaid.
This randomized clinical trial evaluates the safety and efficacy of basimglurant modified-release vs placebo as adjunctive therapy to ongoing antidepressant medication therapy in patients with major depressive disorder who had inadequate response within the current episode.
This case-control study finds evidence of inflammation of the anterior cingular cortex in major depressive episodes (MDE).
This cross-sectional study of positron emission tomography (PET) findings of brainstem raphe binding of serotonin1A in suicide attempters relates the severity of suicidal ideation to brainstem and prefrontal serotonin1A binding potential.
This Viewpoint supports adoption of the Research Domain Criteria (RDoC) initiative to replace categorical with dimensional diagnoses.
This randomized clinical trial notes recurrence of depressive symptoms in perimenopausal women during estradiol withdrawal. See also the editorial by Newhouse and Albert.
Nurnberger et al identify biological pathways that contribute to risk for bipolar disorder using genes with consistent evidence for association in multiple genome-wide association studies.
This multisite, randomized clinical trial finds that venlafaxine XR was well tolerated by most patients and an effective antidepressant for decreasing core symptoms of depression and improving spinal cord injury–related disability.
Johnson et al determine the efficacy of topiramate vs placebo as a treatment for cocaine dependence.