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  • Association Between Chronic Physical Conditions and the Effectiveness of Collaborative Care for Depression: An Individual Participant Data Meta-analysis

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    JAMA Psychiatry. 2016; 73(9):978-989. doi: 10.1001/jamapsychiatry.2016.1794

    This meta-analysis of trials comparing collaborative to usual care in adults with depression uses individual participant data to investigate if chronic comorbidities modify the effects of the intervention.

  • Evaluation of the Persistence, Remission, and Emergence of Attention-Deficit/Hyperactivity Disorder in Young Adulthood

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    JAMA Psychiatry. 2016; 73(7):713-720. doi: 10.1001/jamapsychiatry.2016.0465

    This study investigates childhood risk factors and functioning in young adults with persistent, remitted, and late-onset ADHD.

  • Self-harm, Unintentional Injury, and Suicide in Bipolar Disorder During Maintenance Mood Stabilizer Treatment: A UK Population-Based Electronic Health Records Study

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    JAMA Psychiatry. 2016; 73(6):630-637. doi: 10.1001/jamapsychiatry.2016.0432

    This longitudinal cohort study compares rates of self-harm, unintentional injury, and suicide in patients with bipolar disorder prescribed lithium, valproate sodium, olanzapine, or quetiapine fumarate.

  • Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks

    Abstract Full Text
    JAMA Psychiatry. 2016; 73(5):472-480. doi: 10.1001/jamapsychiatry.2016.0036

    This genome-wide association study assesses analyses from 3 studies of substance use disorder genetics to identify DSM-IV criteria for cannabis dependence in a large African American and European American cohort.

  • Genome-wide Significant Associations for Cannabis Dependence Severity: Relevance to Psychiatric Disorders

    Abstract Full Text
    JAMA Psychiatry. 2016; 73(5):443-444. doi: 10.1001/jamapsychiatry.2016.0046
  • Predictors and Moderators of Remission With Aripiprazole Augmentation in Treatment-Resistant Late-Life Depression: An Analysis of the IRL-GRey Randomized Clinical Trial

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    JAMA Psychiatry. 2016; 73(4):329-336. doi: 10.1001/jamapsychiatry.2015.3447

    This analysis of a randomized clinical trial tests the moderating role of pretreatment executive function, severity of anxiety, and severity of medical comorbidity in remission of treatment-resistant late-life depression after aripiprazole augmentation.

  • Mortality Among Persons With Obsessive-Compulsive Disorder in Denmark

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    JAMA Psychiatry. 2016; 73(3):268-274. doi: 10.1001/jamapsychiatry.2015.3105

    This cohort study, using a national longitudinal registry, estimates mortality risk of persons with obsessive-compulsive disorder compared with those without this disorder.

  • Familial Liability for Eating Disorders and Suicide Attempts: Evidence From a Population Registry in Sweden

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    JAMA Psychiatry. 2016; 73(3):284-291. doi: 10.1001/jamapsychiatry.2015.2737

    This cohort study examines the association between eating disorders and suicide attempts, with further analyses of familial associations as risk factors.

  • Phenotypic Manifestation of Genetic Risk for Schizophrenia During Adolescence in the General Population

    Abstract Full Text
    JAMA Psychiatry. 2016; 73(3):221-228. doi: 10.1001/jamapsychiatry.2015.3058

    This study uses data from the Avon Longitudinal Study of Parents and Children to investigate the association of genetic risk for schizophrenia with different phenotypes in a population-based birth cohort of adolescents.

  • Association of Mental Disorders With Subsequent Chronic Physical Conditions: World Mental Health Surveys From 17 Countries

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    JAMA Psychiatry. 2016; 73(2):150-158. doi: 10.1001/jamapsychiatry.2015.2688

    This study of World Mental Healthy Surveys from 17 countries investigates the association between mental disorders and the subsequent development of chronic physical diseases.

  • Defining the Effect of the 16p11.2 Duplication on Cognition, Behavior, and Medical Comorbidities

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    JAMA Psychiatry. 2016; 73(1):20-30. doi: 10.1001/jamapsychiatry.2015.2123

    This international cohort study assesses the effects of the 16p11.2 duplication on cognitive, behavioral, medical, and anthropometric traits in carriers and compared these findings with effects in 16p11.2 deletion carriers and the relatives of both groups.

  • Epidemiology of DSM-5 Drug Use Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions–III

    Abstract Full Text
    JAMA Psychiatry. 2016; 73(1):39-47. doi: 10.1001/jamapsychiatry.2015.2132

    This survey study presents nationally representative findings on the prevalence, correlates, psychiatric comorbidity, disability, and treatment of DSM-5 drug use disorder diagnoses overall and by severity level.

  • Occurrence and Recurrence of Attempted Suicide Among People With Epilepsy

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    JAMA Psychiatry. 2016; 73(1):80-86. doi: 10.1001/jamapsychiatry.2015.2516

    This cohort study reports on the magnitude of the association between attempted suicide and epilepsy.

  • Cortical and Subcortical Gray Matter Volume in Youths With Conduct Problems: A Meta-analysis

    Abstract Full Text
    JAMA Psychiatry. 2016; 73(1):64-72. doi: 10.1001/jamapsychiatry.2015.2423

    This meta-analysis of whole-brain structural neuroimaging studies of youths with conduct problems identifies gray matter reductions within the insula, amygdala, and frontal and temporal regions.

  • Self-blame–Selective Hyperconnectivity Between Anterior Temporal and Subgenual Cortices and Prediction of Recurrent Depressive Episodes

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    JAMA Psychiatry. 2015; 72(11):1119-1126. doi: 10.1001/jamapsychiatry.2015.1813

    Among 75 medication-free patients with remitted major depressive disorder and no relevant comorbidity, this prospective cohort study tests the hypothesis that RSATL-SCSR connectivity for self-blaming relative to other-blaming emotions predicts subsequent recurrence of depressive episodes.

  • Epidemiology of DSM-5 Alcohol Use Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions III

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    JAMA Psychiatry. 2015; 72(8):757-766. doi: 10.1001/jamapsychiatry.2015.0584

    This national epidemiologic survey finds that alcohol use disorder is highly prevalent, highly comorbid, and disabling, with an urgent need for education of the public and policy makers, destigmatization of the disorder, and encouragement of those with the disorder to seek treatment.

  • Transdiagnostic Factors and Mediation of the Relationship Between Perceived Racial Discrimination and Mental Disorders

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    JAMA Psychiatry. 2015; 72(7):706-713. doi: 10.1001/jamapsychiatry.2015.0148

    To examine the direct and indirect relationships between perceived racial discrimination and common forms of psychopathology, 12 common diagnoses were assessed in a nationally representative sample of African American and Afro-Caribbean adults.

  • Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder

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    JAMA Psychiatry. 2015; 72(7):642-650. doi: 10.1001/jamapsychiatry.2015.0554

    This genome-wide association analysis identifies a novel locus for neuroticism and shows polygenic association with major depressive disorder (MDD).

  • Extended-Release Mixed Amphetamine Salts vs Placebo for Comorbid Adult Attention-Deficit/Hyperactivity Disorder and Cocaine Use Disorder: A Randomized Clinical Trial

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    JAMA Psychiatry. 2015; 72(6):593-602. doi: 10.1001/jamapsychiatry.2015.41

    This randomized clinical trial in patients with comorbid adult attention-deficit/hyperactivity disorder (ADHD) and cocaine use disorder examined whether extended-release mixed amphetamine salts are effective for both improving symptoms of ADHD and reducing cocaine use.

  • Effect of Depression and Diabetes Mellitus on the Risk for Dementia: A National Population-Based Cohort Study

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    JAMA Psychiatry. 2015; 72(6):612-619. doi: 10.1001/jamapsychiatry.2015.0082

    This population-based cohort study reports an independent association of depression and diabetes mellitus (DM) with the risk for dementia in a national population sample from medical registries. See also the Invited Commentary by Reynolds.