This population-based longitudinal study investigates the association of circulating levels of vitamin B12, folate, and sulfur amino acids with the rate of total brain volume loss and the change in white matter hyperintensity volume in older adults.
This prospective cohort study of black and white community-dwelling older adults in the Health, Aging, and Body Composition study investigates the association between trajectories of depressive symptoms and risk of dementia in older adults.
This analysis of a randomized clinical trial tests the moderating role of pretreatment executive function, severity of anxiety, and severity of medical comorbidity in remission of treatment-resistant late-life depression after aripiprazole augmentation.
This article seeks todetermine whether rates of dementia were associated with average altitude of residence in 58 California counties.
This 18-year cohort study of more than 2.8 million individuals in Denmark reports that the risk of dementia was more than 2-fold higher among those with schizophrenia, especially those younger than 65 years, compared with those without schizophrenia.
This multicenter collaborative study explores whether biologically defined groups of genes are enriched in episodic memory performance across age, memory encoding–related brain activity, and Alzheimer disease.
This population-based cohort study reports an independent association of depression and diabetes mellitus (DM) with the risk for dementia in a national population sample from medical registries. See also the Invited Commentary by Reynolds.
This case-control study examines whether mortality increases in elderly patients with dementia who receive antipsychotic medications.
This prospective longitudinal cohort study determines whether early cognitive decline is associated with risk of psychotic disorder in patients with 22q11.2 deletion syndrome.
This randomized clinical trial reports that problem adaptation therapy was more efficacious than supportive therapy for cognitively impaired patients in reducing depression and disability. Problem adaptation therapy may provide relief to a large group of depressed and cognitively impaired older adults with few treatment options.
To test the hypothesis that neurodegeneration and neuronal density in brainstem aminergic nuclei are related to late-life depression, Wilson et al performed a clinicopathological cohort study among 124 older persons without dementia who had annual evaluations (with self-report of depressive symptoms), died, and underwent a postmortem neuropathological examination.