This longitudinal cohort study compares rates of self-harm, unintentional injury, and suicide in patients with bipolar disorder prescribed lithium, valproate sodium, olanzapine, or quetiapine fumarate.
In a 2-center cross-sectional study, Redlich et al investigate and compare morphometric changes in unipolar depression (UD) and bipolar depression (BD), and replicate the findings at 2 independent neuroimaging sites. They conclude that individuals with UD and those with BD are differentiated by structural abnormalities in neural regions supporting emotion processing.
Khan et al assessed mortality risk among adult patients with a diagnosis of schizophrenia, depression, bipolar disorder, anxiety disorder, or attention-deficit/hyperactivity disorder participating in clinical trials and evaluated if psychopharmacological agents worsen this risk.
Nurnberger et al identify biological pathways that contribute to risk for bipolar disorder using genes with consistent evidence for association in multiple genome-wide association studies.
This study uses civil and psychiatric national registers to evaluate patterns and correlates in 10-year trajectories associated with the diagnosis of major depressive disorder in a Danish population.