Lasserre and colleagues aimed to determine whether the subtypes of major depressive disorder (MDD; melancholic, atypical, combined, or unspecified) are predictive of adiposity in terms of the incidence of obesity and changes in body mass index (calculated as weight in kilograms divided by height in meters squared), waist circumference, and fat mass.
Khan et al assessed mortality risk among adult patients with a diagnosis of schizophrenia, depression, bipolar disorder, anxiety disorder, or attention-deficit/hyperactivity disorder participating in clinical trials and evaluated if psychopharmacological agents worsen this risk.
This randomized trial compares the effects of metformin vs placebo on weight gain in children and adolescents with autism spectrum disorder taking atypical antipsychotics.
Fishman and colleagues investigate whether adolescents with autism spectrum disorder show altered functional connectivity in 2 brain networks putatively impaired in autism spectrum disorder and involved in social processing, the mentalizing theory of mind and mirror neuron systems.
This prospective longitudinal study provides evidence that structural abnormalities in anterior insula volume are related to the neurobiology of depressive disorders starting in early childhood.
Hollon et al determine the effects of combining cognitive therapy with antidepressant medications vs antidepressant medications alone on remission and recovery in major depressive disorder. See the editorial by Thase.