This randomized clinical trial examines whether the effects of methylphenidate on the dopaminergic system are modified by age and tests the hypothesis that methylphenidate treatment of young but not adult patients with attention-deficit/hyperactivity disorder induces lasting effects.
This case-control study examines whether the pattern of brain connectivity across striatal subregions is abnormal in unmedicated patients with schizophrenia and whether this abnormality relates to psychotic symptoms and extrastriatal dopaminergic transmission.
This article discusses advances in the study of corticostriatal circuits and the involvement of these circuits in psychiatric disorders such as schizophrenia.
This cohort study investigates associations between striatal activity (measured via functional magnetic resonance imaging) during reward anticipation and weight change induced by amisulpride, a selective dopamine D2 receptor antagonist, among antipsychotic-naive patients with schizophrenia.
This meta-analysis of functional magnetic resonance imaging studies assessed the differences between patients with schizophrenia spectrum disorders and healthy controls in ventral striatal activation during reward processing.
This positron emission tomographic functional magnetic resonance imaging study found in vivo evidence for a deficit in the capacity for dopamine release in the dorsolateral prefrontal cortex in schizophrenia.
This study presents preliminary evidence of dopamine sensitization in a socially excluded group of people with hearing impairment.
Konova et al examine changes in mesocorticolimbic connectivity with methylphenidate and how connectivity of affected pathways relates to severity of cocaine addiction in 18 nonabstaining individuals with cocaine use disorders.