This meta-analysis reports that the average treatment change associated with placebo treatment in antipsychotic trials increased since 1960, while the change associated with medication treatment decreased.
This randomized trial compares the efficacy of targeted complicated grief treatment, citalopram, both, or neither on the outcomes of patients with complicated grief.
This case-control study examines whether mortality increases in elderly patients with dementia who receive antipsychotic medications.
This cross-sectional imaging study identifies the effects of prenatal polycyclic aromatic hydrocarbon exposure on brain structure and assesses the cognitive and behavioral correlates of those abnormalities in school-age children.
This meta-analysis of 6 placebo-controlled studies examines whether the baseline severity of schizophrenia influences the efficacy of antipsychotic drugs.
This positron emission tomographic functional magnetic resonance imaging study found in vivo evidence for a deficit in the capacity for dopamine release in the dorsolateral prefrontal cortex in schizophrenia.
This cohort study examines the precise nature of the association between continued cannabis use after the onset of psychosis and risk of relapse of psychosis.
There have been a number of mainstream media reports that the abuse of heroin has migrated from low-income urban areas with large minority populations to more affluent suburban and rural areas with primarily white populations. Cicero et al examine the veracity of these anecdotal reports and define the relationship between the abuse of prescription opioids and the abuse of heroin.
The SALOME randomized clinical trial tests if injectable hydromorphone is noninferior to injectable diacetylmorphine in reducing illicit heroin use after 6 months of intervention.