This population-based longitudinal study investigates the association of circulating levels of vitamin B12, folate, and sulfur amino acids with the rate of total brain volume loss and the change in white matter hyperintensity volume in older adults.
This prospective cohort study of black and white community-dwelling older adults in the Health, Aging, and Body Composition study investigates the association between trajectories of depressive symptoms and risk of dementia in older adults.
This study compares mental health symptom monitoring alone vs symptom monitoring plus care management among 1018 older, community-dwelling, low-income adults prescribed an antidepressant or anxiolytic and experiencing clinically significant mental health symptoms at intake.
This multicenter collaborative study explores whether biologically defined groups of genes are enriched in episodic memory performance across age, memory encoding–related brain activity, and Alzheimer disease.
This randomized clinical trial examines the effects of telephone-delivered cognitive-behavioral therapy compared with telephone-delivered nondirective supportive therapy in rural older adults with generalized anxiety disorder.
This open-label pharmacological trial uses group-based trajectory modeling to assess patterns of response to extended-release venlafaxine for late-life depression in older adults and the clinical factors associated with these patterns.
This case-control study examines whether mortality increases in elderly patients with dementia who receive antipsychotic medications.
This multicenter, prospective cohort study provides support for the deleterious effect of elevated amyloid-β levels on cognitive function in preclinical Alzheimer disease.
This retrospective descriptive analysis reports that despite cautions concerning risks associated with long-term benzodiazepine use, especially in older patients, long-term benzodiazepine use remains common in this age group. More vigorous clinical interventions supporting judicious benzodiazepine use may be needed to decrease rates of long-term benzodiazepine use in older adults.
This randomized clinical trial reports that problem adaptation therapy was more efficacious than supportive therapy for cognitively impaired patients in reducing depression and disability. Problem adaptation therapy may provide relief to a large group of depressed and cognitively impaired older adults with few treatment options.
This randomized clinical trial found that complicated grief (CG) treatment produced clinically and statistically significantly greater response rates for symptoms of CG in the elderly than a proven efficacious treatment for depression.
Bernert et al examine the relative independent risk for suicide associated with poor subjective sleep quality in a population-based study of older adults during a 10-year observation period. Four hundred controls were matched to 20 suicide decedents. Primary measures included the Sleep Quality Index, a depression scale, and vital statistics.
Byers et al determine the association between posttraumatic stress disorder (PTSD) and disability among older adults and investigate if association differs by chronicity of PTSD.
Blazer discusses independent research by early investigators.
Sutin et al estimated the trajectory of depressive symptoms across the adult life span, tested whether it varies by demographic factors and antidepressant medication use, and tested whether disease burden, functional limitations, and proximity to death explain the increase in depressive symptoms in old age.