This meta-analysis of observational studies investigates associations between age at menopause, duration of the reproductive period, and depression in postmenopausal women.
This Neuroscience and Psychiatry article proposes that changing levels of estradiol may directly modify the activity of dorsal and ventral emotional regulation nodes and circuits, modifying the cognitive and emotional consequences of life stress and leading to depression in women.
This randomized clinical trial compares the effects of adjunctive raloxifene with antipsychotic therapy vs antipsychotics alone on illness severity in women with refractory schizophrenia.
Rekkas et al investigate whether monoamine oxidase A (MAO-A) total distribution volume (VT), an index of MAO-A density, is elevated in women of perimenopausal age (41-51 years). Epperson et al provide commentary in a related editorial.
This randomized clinical trial notes recurrence of depressive symptoms in perimenopausal women during estradiol withdrawal. See also the editorial by Newhouse and Albert.
This nationwide cohort study investigates whether the use of hormonal contraception is positively associated with subsequent use of antidepressants and a diagnosis of depression among women in Denmark.