This randomized clinical trial investigates the preliminary finding that the sweet-liking phenotype interacts with a high level of craving for alcohol to improve the response to naltrexone in patients with alcohol dependence.
This nonrandomized trial compares the effects of an intervention comprising manual-guided sessions on health care engagement and health information technology use vs usual care on self-reported substance use and depression.
This cohort study uses national survey data to examine associations between cannabis use and risk of mental health and substance use disorders in the general US adult population.
This survey study presents nationally representative findings on the prevalence, correlates, psychiatric comorbidity, disability, and treatment of DSM-5 drug use disorder diagnoses overall and by severity level.
This national epidemiologic survey finds that alcohol use disorder is highly prevalent, highly comorbid, and disabling, with an urgent need for education of the public and policy makers, destigmatization of the disorder, and encouragement of those with the disorder to seek treatment.
This prospective cohort study reports that achieving remission from a substance use disorder does not typically lead to drug substitution, but rather is associated with a lower risk of new substance use disorder onsets.
Lahey et al test predictions derived from a hierarchical-dimensional model of psychopathology that (1) heterotypic continuity is widespread, even controlling for homotypic continuity, and that (2) the relative magnitudes of heterotypic continuities recapitulate the relative magnitudes of cross-sectional correlations among diagnoses at baseline.
Alati and colleagues compare alcohol use by young women born in Australia from 1981 to 1983 at 21 years of age with that of their mothers at the same age.
Kühn and colleagues investigate the effect of alcohol abstinence on neuronal plasticity measured as longitudinal volume change in distinct hippocampal subfields.
Gustafson et al determine whether patients leaving residential treatment for alcohol use disorders with a smartphone application to support recovery have fewer risky drinking days than control patients.
Hartz and colleagues compared substance use in individuals with severe psychotic illness with substance use in the general population.
Crum et al used data from the National Epidemiologic Survey on Alcohol and Related Conditions to evaluate the hypothesis that alcohol self-medication of mood symptoms increases the probability of subsequent onset and the persistence or chronicity of alcohol dependence.
Seo and colleagues aimed to identify neural correlates associated with alcohol craving and relapse outcomes in 45 treatment-engaged, 4- to 8-week–abstinent alcohol-dependent patients, and compare brain responses of 30 demographically matched alcohol-dependent patients and 30 healthy control subjects during stress, alcohol, and neutral-relaxing cues. Volkow and Baler provide a related editorial.