This cross-sectional study reports that κ-opioid receptor availability in an amygdala–anterior cingulate cortex–ventral striatal neural circuit mediates the phenotypic expression of trauma-related loss (ie, dysphoria) symptoms and that an activated corticotropin-releasing factor/hypothalamic-pituitary-adrenal axis system may indirectly mediate this association.
This study identifies a potential systems-level intermediate phenotype linked to emotion processing in schizophrenia and examines the psychological association, task specificity, test-retest reliability, and clinical validity of the identified phenotype.
This cross-sectional study reports that medication-free patients with major depressive disorder vs bipolar disorder appear to differ in brain activations during emotion regulation, both while depressed and in remission.
Moeller and coauthors investigate the neural correlates of impaired insight in addiction using a combined functional magnetic resonance imaging and voxel-based morphometry approach.
To examine whether early child care moderates associations between maternal depressive symptoms and child internalizing problems (emotional problems, separation anxiety symptoms, and social withdrawal symptoms) during the preschool period, Herba et al performed a population-based prospective cohort study within the Québec Longitudinal Study of Child Development.