This genetic analysis examines whether neuronal activity-dependent changes of gene expression are dysregulated in schizophrenia.
This exome sequencing study of family members with bipolar disorder from 8 multiplex families tested rare, segregating variants in 3 independent samples, followed by association testing in a large case-control meta-analysis.
This study examines the role of microRNAs in the context of genetic variation associated with schizophrenia.
This study describes the use of a multilevel data-integration approach to identify novel candidate genes for developmental brain disorders.
This multicenter collaborative study explores whether biologically defined groups of genes are enriched in episodic memory performance across age, memory encoding–related brain activity, and Alzheimer disease.
This epigenetic association study investigates whether aberrant DNA methylation contributes to circuit- and diagnosis-specific abnormal expression of GAD1 regulatory network genes in schizophrenia and bipolar disorder.
This proof-of-principle study demonstrated that genomic biomarkers with very good sensitivity and specificity for boys with autism spectrum disorder in general pediatric settings can be identified.
Nurnberger et al identify biological pathways that contribute to risk for bipolar disorder using genes with consistent evidence for association in multiple genome-wide association studies.
Dima et al determine whether genetic risk for bipolar disorder associated with CACNA1C rs1006737 and ANK3 rs10994336 is mediated through changes in regional activation and interregional connectivity of the facial affect–processing network.
Blasi et al examine the functional effects of the serotonin receptor 2a (5-HT2AR) gene on 5-HT2AR
messenger RNA and protein expression, on prefrontal phenotypes linked with genetic risk for
schizophrenia, and on treatment with olanzapine.