This genome-wide association study assesses analyses from 3 studies of substance use disorder genetics to identify DSM-IV criteria for cannabis dependence in a large African American and European American cohort.
This epigenome-wide association study examines differentially methylated positions across the genome in blood-derived DNA samples in a discovery and a replication set.
This twin study uses structural equation modeling to examine whether white matter integrity is associated with the genetic liability for developing schizophrenia.
This international cohort study assesses the effects of the 16p11.2 duplication on cognitive, behavioral, medical, and anthropometric traits in carriers and compared these findings with effects in 16p11.2 deletion carriers and the relatives of both groups.
This population-based twin study estimates that the liability to autism spectrum disorder derives primarily from additive genetic and to a lesser extent nonshared environmental effects.
This cross-sectional study demonstrates that psychiatric comorbidities are common among individuals with Tourette syndrome and that most comorbidities begin early in life.
This latent class analysis of obsessive-compulsive (OC) features, cross-sectional tests of association, and classic twin genetic analysis finds phenotypic and genetic overlap between OC and pathological gambling.
This cohort study using 8 public data registers reports that parent-offspring transmission of alcohol use disorder results from both genetic and environmental factors.
This family-based analysis of de novo copy number variants finds significant parent-proband correlations between family background and phenotypic variability.
This study concludes that the robust joint test be used in candidate-gene and genome-wide association studies of psychiatric outcomes that consider environmental interactions.
This Viewpoint discusses lessons learned from a recent article from the Schizophrenia Working Group of the Psychiatric Genomics Consortium on 108 schizophrenia-associated genetic loci.
Zavos et al investigate the degree of genetic and environmental influences, as well as the degree of overlap of etiological influences, on specific psychotic experiences in adolescents and in individuals with many, frequent experiences. See also the editorial by van Os.
Waszczuk and colleagues investigated the phenotypic associations between depression and anxiety disorder symptom subscales and tested the genetic structures underlying these symptoms (DSM-5–related, unidimensional and bidimensional) across 3 developmental stages: childhood, adolescence, and early adulthood.
Ljung et al explore whether attention-deficit/hyperactivity disorder (ADHD) and suicidal behavior share genetic and environmental risk factors.
Maciejewski et al determine the relative importance of genetic and environmental influences on the variation in nonsuicidal self-injury and suicidal ideation and their covariation.
Fears et al aim to identify quantitative neurocognitive, temperament-related, and neuroanatomical phenotypes that appear heritable and associated with severe bipolar disorder (BP) (bipolar I disorder) and therefore suitable for genetic linkage and association studies aimed at identifying variants contributing to bipolar I disorder risk.
Rasetti and colleagues investigated whether altered brain responses, particularly in the hippocampus and parahippocampus, during the encoding phase of a simple declarative memory task were also observed in the unaffected siblings of patients with schizophrenia.
Monzani et al estimate the degree to which genetic and environmental risk factors are shared and/or unique to dimensionally scored obsessive compulsive disorder, body dysmorphic disorder, hoarding disorder, trichotillomania (hair-pulling disorder), and excoriation (skin-picking) disorder.