This multicenter collaborative study explores whether biologically defined groups of genes are enriched in episodic memory performance across age, memory encoding–related brain activity, and Alzheimer disease.
This genome-wide association analysis identifies a novel locus for neuroticism and shows polygenic association with major depressive disorder (MDD).
Blasi et al examine the functional effects of the serotonin receptor 2a (5-HT2AR) gene on 5-HT2AR
messenger RNA and protein expression, on prefrontal phenotypes linked with genetic risk for
schizophrenia, and on treatment with olanzapine.
Waszczuk and colleagues investigated the phenotypic associations between depression and anxiety disorder symptom subscales and tested the genetic structures underlying these symptoms (DSM-5–related, unidimensional and bidimensional) across 3 developmental stages: childhood, adolescence, and early adulthood.
This Viewpoint discusses lessons learned from a recent article from the Schizophrenia Working Group of the Psychiatric Genomics Consortium on 108 schizophrenia-associated genetic loci.
This population-based twin study estimates that the liability to autism spectrum disorder derives primarily from additive genetic and to a lesser extent nonshared environmental effects.
Maciejewski et al determine the relative importance of genetic and environmental influences on the variation in nonsuicidal self-injury and suicidal ideation and their covariation.