This study assesses whether certain factors identified with structural magnetic resonance imaging techniques are able to predict response to electroconvulsive therapy in patients with major depressive disorder.
This review reports on what has been learned about the network mechanisms that underlie abnormal delta oscillations.
This multicenter collaborative study explores whether biologically defined groups of genes are enriched in episodic memory performance across age, memory encoding–related brain activity, and Alzheimer disease.
This epigenetic association study investigates whether aberrant DNA methylation contributes to circuit- and diagnosis-specific abnormal expression of GAD1 regulatory network genes in schizophrenia and bipolar disorder.
This retrospective analysis describes features of anterior cingulate cortex structure and connectivity that predict clinical response to dorsal anterior cingulotomy for treatment of refractory obsessive-compulsive disorder. See also the editorial by van den Heuvel.
In a 2-center cross-sectional study, Redlich et al investigate and compare morphometric changes in unipolar depression (UD) and bipolar depression (BD), and replicate the findings at 2 independent neuroimaging sites. They conclude that individuals with UD and those with BD are differentiated by structural abnormalities in neural regions supporting emotion processing.
Van Dam et al identify structural neural characteristics independently associated with childhood maltreatment, comparing a sample with substance use disorders with a demographically comparable control sample, and they examine the relationship between childhood maltreatment–related structural brain changes and subsequent relapse.
Mathew et al characterize medial temporal lobe structures, including hippocampal subfields, using magnetic resonance imaging and examine their relation to psychosis and cognitive function across the psychosis spectrum.
Kühn and colleagues investigate the effect of alcohol abstinence on neuronal plasticity measured as longitudinal volume change in distinct hippocampal subfields.
Rasetti and colleagues investigated whether altered brain responses, particularly in the hippocampus and parahippocampus, during the encoding phase of a simple declarative memory task were also observed in the unaffected siblings of patients with schizophrenia.
To examine the neural correlates of recall of life events judged to be of causal significance in conversion disorder (CD), Aybek et al performed an fMRI study of 12 patients with motor CD and 13 healthy control subjects. Stressful life events were assessed using the Life Events and Difficulties Schedule and rated for their likelihood to cause CD.
In a combined 3-T structural magnetic resonance imaging and single-voxel proton magnetic resonance spectroscopy study, Kraguljac and coauthors evaluate hippocampal volumetric measures and neurometabolite levels in unmedicated patients with schizophrenia and the correlations between these markers. See the editorial by Öngür.