This randomized clinical trial evaluates the safety and efficacy of basimglurant modified-release vs placebo as adjunctive therapy to ongoing antidepressant medication therapy in patients with major depressive disorder who had inadequate response within the current episode.
This study of patients with major depressive disorder reports that a more densely connected symptom network is associated with persistent depression.
Lasserre and colleagues aimed to determine whether the subtypes of major depressive disorder (MDD; melancholic, atypical, combined, or unspecified) are predictive of adiposity in terms of the incidence of obesity and changes in body mass index (calculated as weight in kilograms divided by height in meters squared), waist circumference, and fat mass.
Wallace et al demonstrate a novel exploratory approach to moderation analysis with a sample of 291 adults from a randomized clinical trial that compared an empirically supported psychotherapy and selective serotonin reuptake inhibitor pharmacotherapy as treatments for depression.
In an observational, longitudinal study, Judd and coauthors determine the prevalence of overtly expressed irritability/anger and its effect on intake presentation and the long-term course of illness.