This laboratory-based cross-sectional study assesses cue-induced craving for cocaine in adults using both subjective and objective indices of cue-elicited responses.
This study compares mental health symptom monitoring alone vs symptom monitoring plus care management among 1018 older, community-dwelling, low-income adults prescribed an antidepressant or anxiolytic and experiencing clinically significant mental health symptoms at intake.
This study of brain tissue suggests that lower expression of NARP may lower the excitatory drive in schizophrenia.
This prospective cohort and risk score development study determines that risk prediction models for cardiovascular disease using body mass index and lipid levels perform better in people with severe mental illness compared with models that include only established risk factors.
This cross-sectional study of positron emission tomography (PET) findings of brainstem raphe binding of serotonin1A in suicide attempters relates the severity of suicidal ideation to brainstem and prefrontal serotonin1A binding potential.
This cross-sectional study reports that κ-opioid receptor availability in an amygdala–anterior cingulate cortex–ventral striatal neural circuit mediates the phenotypic expression of trauma-related loss (ie, dysphoria) symptoms and that an activated corticotropin-releasing factor/hypothalamic-pituitary-adrenal axis system may indirectly mediate this association.
Lautner et al evaluate whether the apolipoprotein E genotype affects the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease (AD) and whether the association of the ε4 allele with biomarkers depends on cortical β-amyloid status.
Johnson et al determine the efficacy of topiramate vs placebo as a treatment for cocaine dependence.