This randomized clinical trial examines whether the effects of methylphenidate on the dopaminergic system are modified by age and tests the hypothesis that methylphenidate treatment of young but not adult patients with attention-deficit/hyperactivity disorder induces lasting effects.
This pharmacoepidemiology study uses BCBS claims data to characterize recent trends in use of methylphenidate and amphetamine-related products in 4 US states between 2010 and 2014.
This randomized clinical trial compares the efficacy of cognitive behavioral group psychotherapy vs individual clinical management and methylphenidate vs placebo in patients with adult attention-deficit/hyperactivity disorder.
This prospective study does not identify any involvement of changes in brain norepinephrine transporter availability or distribution in the pathogenesis of attention-deficit/hyperactivity disorder.
Konova et al examine changes in mesocorticolimbic connectivity with methylphenidate and how connectivity of affected pathways relates to severity of cocaine addiction in 18 nonabstaining individuals with cocaine use disorders.