This national survey describes the limited effectiveness of an abuse-deterrent formulation of OxyContin and residual abuse among patients in drug treatment programs.
The SALOME randomized clinical trial tests if injectable hydromorphone is noninferior to injectable diacetylmorphine in reducing illicit heroin use after 6 months of intervention.
This placebo trial examines the neurochemical mechanisms underlying the formation of placebo effects in patients with major depressive disorder.
This survey study presents nationally representative findings on the prevalence, correlates, psychiatric comorbidity, disability, and treatment of DSM-5 drug use disorder diagnoses overall and by severity level.
This population epidemiology study uses data from the US Centers for Disease Control and Prevention to compare trends and patterns of mortality from self-injury with those from diabetes, influenza and pneumonia, and kidney disease between 1999 and 2014.
In a proof-of-concept, randomized, double-blind, crossover trial comparing ketamine with an active placebo control, midazolam, conducted at a single site, Feder and coauthors test the efficacy and safety of a single intravenous subanesthetic dose of ketamine for the treatment of posttraumatic stress disorder (PTSD) and associated depressive symptoms in patients with chronic PTSD.