This national survey describes the limited effectiveness of an abuse-deterrent formulation of OxyContin and residual abuse among patients in drug treatment programs.
Sigmon et al evaluate the relative efficacy of 1-, 2-, and 4-week buprenorphine tapering regimens and subsequent naltrexone therapy in outpatients with prescription opioid dependence.
There have been a number of mainstream media reports that the abuse of heroin has migrated from low-income urban areas with large minority populations to more affluent suburban and rural areas with primarily white populations. Cicero et al examine the veracity of these anecdotal reports and define the relationship between the abuse of prescription opioids and the abuse of heroin.
This cross-sectional study reports that κ-opioid receptor availability in an amygdala–anterior cingulate cortex–ventral striatal neural circuit mediates the phenotypic expression of trauma-related loss (ie, dysphoria) symptoms and that an activated corticotropin-releasing factor/hypothalamic-pituitary-adrenal axis system may indirectly mediate this association.