This Special Communication reviews genetic models that explore the upper boundaries of the consequences of generations of assortative mating for psychiatric traits while acknowledging the limitations of model assumptions.
This randomized clinical trial investigates the preliminary finding that the sweet-liking phenotype interacts with a high level of craving for alcohol to improve the response to naltrexone in patients with alcohol dependence.
This study identifies a potential systems-level intermediate phenotype linked to emotion processing in schizophrenia and examines the psychological association, task specificity, test-retest reliability, and clinical validity of the identified phenotype.
This epigenome-wide association study examines differentially methylated positions across the genome in blood-derived DNA samples in a discovery and a replication set.
This study uses data from the Avon Longitudinal Study of Parents and Children to investigate the association of genetic risk for schizophrenia with different phenotypes in a population-based birth cohort of adolescents.
This study describes the use of a multilevel data-integration approach to identify novel candidate genes for developmental brain disorders.
This twin study uses structural equation modeling to examine whether white matter integrity is associated with the genetic liability for developing schizophrenia.
This international cohort study assesses the effects of the 16p11.2 duplication on cognitive, behavioral, medical, and anthropometric traits in carriers and compared these findings with effects in 16p11.2 deletion carriers and the relatives of both groups.
This prospective study examines the effects of genes and environment on the developmental course of attention-deficit/hyperactivity disorder (ADHD) symptoms from childhood to adolescence.
This latent class analysis of obsessive-compulsive (OC) features, cross-sectional tests of association, and classic twin genetic analysis finds phenotypic and genetic overlap between OC and pathological gambling.
This family-based analysis of de novo copy number variants finds significant parent-proband correlations between family background and phenotypic variability.
Waszczuk and colleagues investigated the phenotypic associations between depression and anxiety disorder symptom subscales and tested the genetic structures underlying these symptoms (DSM-5–related, unidimensional and bidimensional) across 3 developmental stages: childhood, adolescence, and early adulthood.
Mathew et al characterize medial temporal lobe structures, including hippocampal subfields, using magnetic resonance imaging and examine their relation to psychosis and cognitive function across the psychosis spectrum.
Holz and coauthors clarify the influence of maternal smoking during pregnancy on the neural circuitry of response inhibition and its association with related behavioral phenotypes such as attention-deficit/hyperactivity disorder and novelty seeking in the mother’s offspring.