This 2-year observational cohort study investigates whether lower midbrain serotonin transporter binding potential predicts future suicide attempts, intent, and lethality in patients with major depressive disorder.
This case-control study examines whether the pattern of brain connectivity across striatal subregions is abnormal in unmedicated patients with schizophrenia and whether this abnormality relates to psychotic symptoms and extrastriatal dopaminergic transmission.
This study reports on the effects of antipsychotic dose reduction in patients with late-life schizophrenia.
This cross-sectional positron emission tomography study describes an overactive presynaptic serotonin system, with increased serotonin synthesis and transporter availability, in patients with social anxiety disorder.
This positron emission tomographic functional magnetic resonance imaging study found in vivo evidence for a deficit in the capacity for dopamine release in the dorsolateral prefrontal cortex in schizophrenia.
This case-control study finds evidence of inflammation of the anterior cingular cortex in major depressive episodes (MDE).
This cross-sectional study of positron emission tomography (PET) findings of brainstem raphe binding of serotonin1A in suicide attempters relates the severity of suicidal ideation to brainstem and prefrontal serotonin1A binding potential.
This prospective study does not identify any involvement of changes in brain norepinephrine transporter availability or distribution in the pathogenesis of attention-deficit/hyperactivity disorder.
Lautner et al evaluate whether the apolipoprotein E genotype affects the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease (AD) and whether the association of the ε4 allele with biomarkers depends on cortical β-amyloid status.
Rekkas et al investigate whether monoamine oxidase A (MAO-A) total distribution volume (VT), an index of MAO-A density, is elevated in women of perimenopausal age (41-51 years). Epperson et al provide commentary in a related editorial.
Brody et al determine whether the degree of nicotinic acetylcholine receptor upregulation in smokers predicts quitting with a standard course of treatment.
Lee et al conduct a cross-sectional study to determine the synergistic effects of amyloid burden and cerebrovascular disease on cognition in patients with subcortical vascular mild cognitive impairment.
Pietrzak et al performed a cross-sectional positron emission tomography study under resting conditions among 3 study groups (healthy adults, adults exposed to trauma who did not develop posttraumatic stress disorder (PTSD), and adults exposed to trauma who developed PTSD). The [11C]methylreboxetine-binding potential of norepinephrine transporter availability was measured in the locus coeruleus, and PTSD symptom severity was assessed.
McGrath et al identify a candidate neuroimaging treatment-specific biomarker that predicts differential outcome to either medication or psychotherapy.