This meta-analysis of observational studies investigates associations between age at menopause, duration of the reproductive period, and depression in postmenopausal women.
This randomized clinical trial notes recurrence of depressive symptoms in perimenopausal women during estradiol withdrawal. See also the editorial by Newhouse and Albert.
Freeman et al identify within-woman changes in depressive symptoms during a 14-year period around menopause, determine associations of a history of depression with the pattern of depressive symptoms, and evaluate the rate of change in reproductive hormones as predictors of depressive symptoms after menopause.
This randomized clinical trial compares the effects of adjunctive raloxifene with antipsychotic therapy vs antipsychotics alone on illness severity in women with refractory schizophrenia.
This observational study evaluates the effect of physical activity levels and television viewing habits of young adults over a 25-year period on cognitive function at midlife.
This Neuroscience and Psychiatry article proposes that changing levels of estradiol may directly modify the activity of dorsal and ventral emotional regulation nodes and circuits, modifying the cognitive and emotional consequences of life stress and leading to depression in women.
Choong et al for the ODEX team determine whether polymorphisms within CRTC1 are associated with adiposity markers in psychiatric patients and the general population.