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  • Deconstructing Pretest Risk Enrichment to Optimize Prediction of Psychosis in Individuals at Clinical High Risk

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    JAMA Psychiatry. 2016; doi: 10.1001/jamapsychiatry.2016.2707

    This cohort study investigates the characteristics and predictors of pretest probability of psychosis onset in individuals undergoing clinical health risk assessment.

  • Association Between Continued Cannabis Use and Risk of Relapse in First-Episode Psychosis: A Quasi-Experimental Investigation Within an Observational Study

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    JAMA Psychiatry. 2016; doi: 10.1001/jamapsychiatry.2016.2427

    This cohort study examines the precise nature of the association between continued cannabis use after the onset of psychosis and risk of relapse of psychosis.

  • Triggers for Violent Criminality in Patients With Psychotic Disorders

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    JAMA Psychiatry. 2016; 73(8):796-803. doi: 10.1001/jamapsychiatry.2016.1349

    This study uses Swedish national registry data to identify triggers for violent behavior in patients with schizophrenia spectrum and bipolar disorders, and to compare risk in those populations vs healthy controls.

  • Dopamine-Related Disruption of Functional Topography of Striatal Connections in Unmedicated Patients With Schizophrenia

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    JAMA Psychiatry. 2016; 73(8):862-870. doi: 10.1001/jamapsychiatry.2016.0178

    This case-control study examines whether the pattern of brain connectivity across striatal subregions is abnormal in unmedicated patients with schizophrenia and whether this abnormality relates to psychotic symptoms and extrastriatal dopaminergic transmission.

  • Polygenic Risk of Psychosis and Ventral Striatal Activation During Reward Processing in Healthy Adolescents

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    JAMA Psychiatry. 2016; 73(8):852-861. doi: 10.1001/jamapsychiatry.2016.1135

    This cross-sectional study examines whether common risk variants for psychosis are associated with individual variation in the ventral striatum.

  • The Salience of Reward

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    JAMA Psychiatry. 2016; 73(8):777-778. doi: 10.1001/jamapsychiatry.2016.1134
  • Triggering Violence in Psychosis

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    JAMA Psychiatry. 2016; 73(8):769-770. doi: 10.1001/jamapsychiatry.2016.1348
  • Glutamatergic Dysfunction in Schizophrenia Evaluated With Magnetic Resonance Spectroscopy

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    JAMA Psychiatry. 2016; 73(7):649-650. doi: 10.1001/jamapsychiatry.2016.0575
  • Nature of Glutamate Alterations in Schizophrenia: A Meta-analysis of Proton Magnetic Resonance Spectroscopy Studies

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    JAMA Psychiatry. 2016; 73(7):665-674. doi: 10.1001/jamapsychiatry.2016.0442

    This meta-analysis evaluates the levels of glutamate, glutamine, or the combined Glx signals determined with proton magnetic resonance spectroscopy in patients at high risk for schizophrenia as well as in those with first-episode psychosis or chronic schizophrenia.

  • Structural Brain Abnormalities in Youth With Psychosis Spectrum Symptoms

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    JAMA Psychiatry. 2016; 73(5):515-524. doi: 10.1001/jamapsychiatry.2015.3463

    Using a subsample of individuals from the Philadelphia Neurodevelopmental Cohort, this study investigates the presence of structural brain abnormalities in youth with psychosis spectrum symptoms.

  • Genome-wide Significant Associations for Cannabis Dependence Severity: Relevance to Psychiatric Disorders

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    JAMA Psychiatry. 2016; 73(5):443-444. doi: 10.1001/jamapsychiatry.2016.0046
  • Evidence for Genetic Overlap Between Schizophrenia and Age at First Birth in Women

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    JAMA Psychiatry. 2016; 73(5):497-505. doi: 10.1001/jamapsychiatry.2016.0129

    This investigation uses multiple independent genome-wide association study data sets to determine if there is a genetic association between schizophrenia and age at first birth using genetically informative but independently ascertained data sets.

  • Association of DNA Methylation Differences With Schizophrenia in an Epigenome-Wide Association Study

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    JAMA Psychiatry. 2016; 73(5):506-514. doi: 10.1001/jamapsychiatry.2016.0144

    This epigenome-wide association study examines differentially methylated positions across the genome in blood-derived DNA samples in a discovery and a replication set.

  • Mediation of Developmental Risk Factors for Psychosis by White Matter Microstructure in Young Adults With Psychotic Experiences

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    JAMA Psychiatry. 2016; 73(4):396-406. doi: 10.1001/jamapsychiatry.2015.3375

    This cross-sectional study compares white matter myelination and microstructure in individuals with vs without psychotic experiences and examines neurodevelopmental variables associated with the experiences.

  • Assortative Mating—A Missing Piece in the Jigsaw of Psychiatric Genetics

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    JAMA Psychiatry. 2016; 73(4):323-324. doi: 10.1001/jamapsychiatry.2015.3204
  • Analyzing the Role of MicroRNAs in Schizophrenia in the Context of Common Genetic Risk Variants

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    JAMA Psychiatry. 2016; 73(4):369-377. doi: 10.1001/jamapsychiatry.2015.3018

    This study examines the role of microRNAs in the context of genetic variation associated with schizophrenia.

  • How MicroRNAs Are Involved in Splitting the Mind

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    JAMA Psychiatry. 2016; 73(4):409-410. doi: 10.1001/jamapsychiatry.2015.3144

    This commentary provides an introduction to the role of microRNAs in the nervous system and outlines their potential involvement in the pathophysiology of schizophrenia.

  • Prognosis of Brief Psychotic Episodes: A Meta-analysis

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    JAMA Psychiatry. 2016; 73(3):211-220. doi: 10.1001/jamapsychiatry.2015.2313

    This meta-analysis uses 4 operational categories of brief psychotic episodes to look at the risk of recurrence of psychoses after a patient experiences a brief psychotic first episode.

  • Phenotypic Manifestation of Genetic Risk for Schizophrenia During Adolescence in the General Population

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    JAMA Psychiatry. 2016; 73(3):221-228. doi: 10.1001/jamapsychiatry.2015.3058

    This study uses data from the Avon Longitudinal Study of Parents and Children to investigate the association of genetic risk for schizophrenia with different phenotypes in a population-based birth cohort of adolescents.

  • Why We Need a Transdiagnostic Staging Approach to Emerging Psychopathology, Early Diagnosis, and Treatment

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    JAMA Psychiatry. 2016; 73(3):191-192. doi: 10.1001/jamapsychiatry.2015.2868