This case-control study examines whether the pattern of brain connectivity across striatal subregions is abnormal in unmedicated patients with schizophrenia and whether this abnormality relates to psychotic symptoms and extrastriatal dopaminergic transmission.
This meta-analysis compares the risk of psychosis among clinical high-risk individuals with at least 1 of the major inclusion criteria for psychosis.
This population-based household survey of physical and mental health characterizes neuropsychological functioning in adults with psychotic experiences while adjusting for important sociodemographic characteristics and familial factors.
This randomized clinical trial shows that long-acting injectable risperidone resulted in better clinical outcomes than oral risperidone.
This population-based study finds that the pattern of functional abnormalities observed in youth with psychosis spectrum symptoms is similar to that previously found in schizophrenia and help-seeking risk samples.
This prospective controlled study reports that corticostriatal functional dysconnectivity in psychosis is a state-dependent phenomenon. Increased functional connectivity of the striatum with prefrontal and limbic regions may be a biomarker for improvement in symptoms associated with antipsychotic treatment.
Kelleher et al assessed psychotic symptoms (attenuated or frank) as a clinical marker of risk for