This randomized, double-blind, parallel-group, forced-dose titration, placebo-controlled clinical trial demonstrates efficacy for the 50- and 70-mg/d dosages of lisdexamfetamine dimesylate compared with placebo for treatment of binge-eating disorder.
Lopes and colleagues aimed to determine the efficacy and safety of gamma ventral capsulotomy for intractable obsessive-compulsive disorder (OCD) in a double-blind, placebo-controlled, randomized clinical trial.
Umbricht and colleagues aimed to determine the efficacy and safety of bitopertin, a glycine reuptake inhibitor, in patients with schizophrenia and predominant negative symptoms who were stable while taking an antipsychotic treatment. Goff provided a related editorial.
This population-based cohort study finds that a first self-poisoning episode is a strong predictor of subsequent suicide and premature death.