This epigenome-wide association study examines differentially methylated positions across the genome in blood-derived DNA samples in a discovery and a replication set.
This prospective cohort study reports that achieving remission from a substance use disorder does not typically lead to drug substitution, but rather is associated with a lower risk of new substance use disorder onsets.
Rekkas et al investigate whether monoamine oxidase A (MAO-A) total distribution volume (VT), an index of MAO-A density, is elevated in women of perimenopausal age (41-51 years). Epperson et al provide commentary in a related editorial.
Nicodemus and colleagues assessed the association between single nucleotide polymorphisms in ZNF804A and the ZNF804A polygenic score with measures of cognition in cases with psychosis and assessed whether epistasis within the ZNF804A pathway could explain additional variation above and beyond that explained by the polygenic score.