This randomized clinical trial evaluates the effects of deep brain stimulation in patients with treatment-resistant depression and, in a crossover design, compares active and sham phases for possible detection of placebo effects.
Lopes and colleagues aimed to determine the efficacy and safety of gamma ventral capsulotomy for intractable obsessive-compulsive disorder (OCD) in a double-blind, placebo-controlled, randomized clinical trial.
This retrospective analysis describes features of anterior cingulate cortex structure and connectivity that predict clinical response to dorsal anterior cingulotomy for treatment of refractory obsessive-compulsive disorder. See also the editorial by van den Heuvel.
This experimental study in humans and rats reports that organisms have diminished ability to modulate behavior as a function of reward during withdrawal of nicotine.
To examine the neural correlates of recall of life events judged to be of causal significance in conversion disorder (CD), Aybek et al performed an fMRI study of 12 patients with motor CD and 13 healthy control subjects. Stressful life events were assessed using the Life Events and Difficulties Schedule and rated for their likelihood to cause CD.