This randomized trial compares the effects of metformin vs placebo on weight gain in children and adolescents with autism spectrum disorder taking atypical antipsychotics.
This Viewpoint argues that individualized exposure therapy distinguishing between fear of food vs weight gain is important for successful management of anorexia nervosa.
This cohort study investigates associations between striatal activity (measured via functional magnetic resonance imaging) during reward anticipation and weight change induced by amisulpride, a selective dopamine D2 receptor antagonist, among antipsychotic-naive patients with schizophrenia.
This randomized trial suggests that the type of family therapy matters in the treatment of adolescent-onset anorexia nervosa.
Blumenthal and colleagues estimate weight gain associated with specific antidepressants over the 12 months following initial prescription in a large and diverse clinical population.
Using the age at onset of posttraumatic stress disorder (PTSD) symptoms, Kubzansky et al investigate whether women who develop PTSD are more likely than trauma-exposed women without PTSD or those with no trauma or PTSD symptoms to gain weight.
Choong et al for the ODEX team determine whether polymorphisms within CRTC1 are associated with adiposity markers in psychiatric patients and the general population.
The increased mortality associated with schizophrenia is largely due to cardiovascular disease. Treatment with antipsychotics is associated with weight gain and changes in other cardiovascular risk factors. Early identification of modifiable cardiovascular risk factors is a clinical imperative but prospective longitudinal studies of the early cardiometabolic adverse effects of antipsychotic drug treatment other than weight gain have not been previously reviewed.
To assess the methods and reporting of cardiometabolic outcome studies of the first treated episode of psychosis, review key findings, and suggest directions for future research.
PsycINFO, MEDLINE, and Scopus from January 1990 to June 2010.
Subjects were experiencing their first treated episode of psychosis. Subjects were antipsychotic naive or had been exposed to antipsychotics for a short known period at the beginning of the study. Cardiometabolic indices were assessed. Studies used a longitudinal design.
Sixty-four articles were identified describing 53 independent studies; 25 studies met inclusion criteria and were retained for detailed review.
Consolidated Standards of Reporting Trials and Strengthening the Reporting of Observational Studies in Epidemiology checklists were used to assess the methods and reporting of studies. A qualitative review of findings was conducted.
Two key hypotheses were identified based on this review: (1) in general, there is no difference in cardiovascular risk assessed by weight or metabolic indices between individuals with an untreated first episode of psychosis and healthy controls and (2) cardiovascular risk increases after first exposure to any antipsychotic drug. A rank order of drugs can be derived but there is no evidence of significant class differences. Recommended directions for future research include assessing the effect on cardiometabolic outcomes of medication adherence and dosage effects, determining the therapeutic window for antipsychotic use in adults and youth, and testing for moderation of outcomes by demographic factors, including sex and age, and clinical and genetic factors.