This longitudinal cohort study compares rates of self-harm, unintentional injury, and suicide in patients with bipolar disorder prescribed lithium, valproate sodium, olanzapine, or quetiapine fumarate.
This cohort study evaluates military sexual trauma as an independent risk factor for homelessness among male and female veterans.
This cohort study compares the association of child abuse exposure with suicidal ideation, suicide plans, and suicide attempts in the general Canadian population and 2 cohorts from the Canadian Armed Forces.
This 22-year longitudinal study reports that women with highest number of symptoms of posttraumatic stress disorder had a nearly 2-fold increased risk of type 2 diabetes mellitus over follow-up than women with no trauma exposure.
This single-blind randomized clinical trial finds that standard prolonged exposure and eye movement desensitization and reprocessing protocols are effective, safe, and feasible in patients with PTSD and severe psychotic disorders, including current symptoms.
This study concludes that the robust joint test be used in candidate-gene and genome-wide association studies of psychiatric outcomes that consider environmental interactions.
This cross-sectional analysis using the Nurses’ Health Study II cohort reports that posttraumatic stress disorder symptoms are associated with increased food addiction prevalence. Strategies aimed at reducing obesity associated with posttraumatic stress disorder may require psychological and behavioral interventions that address dependence on food and/or use of food to cope with distress.
This cross-sectional study reports that κ-opioid receptor availability in an amygdala–anterior cingulate cortex–ventral striatal neural circuit mediates the phenotypic expression of trauma-related loss (ie, dysphoria) symptoms and that an activated corticotropin-releasing factor/hypothalamic-pituitary-adrenal axis system may indirectly mediate this association.
Liberzon et al examine the association of 3755 candidate gene SNPs with PTSD development in interaction with a history of childhood trauma. They performed a genetic association study in an Ohio National Guard longitudinal cohort, with replication in an independent Grady Trauma Project (Atlanta, Georgia) civilian cohort.
Lagarde and colleagues aimed to assess whether persistent symptoms 3 months following head injury are specific to mild traumatic brain injury (MTBI) or whether they are better described as part of posttraumatic stress disorder (PTSD) vs postconcussion syndrome (PCS).
Van Dam et al identify structural neural characteristics independently associated with childhood maltreatment, comparing a sample with substance use disorders with a demographically comparable control sample, and they examine the relationship between childhood maltreatment–related structural brain changes and subsequent relapse.
Using the age at onset of posttraumatic stress disorder (PTSD) symptoms, Kubzansky et al investigate whether women who develop PTSD are more likely than trauma-exposed women without PTSD or those with no trauma or PTSD symptoms to gain weight.
Pietrzak et al performed a cross-sectional positron emission tomography study under resting conditions among 3 study groups (healthy adults, adults exposed to trauma who did not develop posttraumatic stress disorder (PTSD), and adults exposed to trauma who developed PTSD). The [11C]methylreboxetine-binding potential of norepinephrine transporter availability was measured in the locus coeruleus, and PTSD symptom severity was assessed.
Eftekhari et al evaluated the effectiveness of prolonged exposure therapy as implemented in a
large number of veterans with posttraumatic stress disorder as part of ongoing efforts to transform
care in a large health care system.
Bryant and colleagues test the roles of initial psychiatric reactions, mild traumatic brain injury, and ongoing stressors on delayed-onset posttraumatic stress disorder.