This randomized clinical trial examines the relative efficacy of weight-adjusted d-cycloserine (25 or 50 mg) vs placebo augmentation of cognitive behavior therapy for youth with obsessive-compulsive disorder and assesses if concomitant antidepressant medication moderated effects.
This randomized clinical trial examines whether d-cycloserine augments cognitive behavioral therapy in the treatment of obsessive-compulsive disorder (OCD) and whether concomitant use of antidepressants moderates the effects of d-cycloserine.
This retrospective analysis describes features of anterior cingulate cortex structure and connectivity that predict clinical response to dorsal anterior cingulotomy for treatment of refractory obsessive-compulsive disorder. See also the editorial by van den Heuvel.
Lopes and colleagues aimed to determine the efficacy and safety of gamma ventral capsulotomy for intractable obsessive-compulsive disorder (OCD) in a double-blind, placebo-controlled, randomized clinical trial.
Simpson et al compare the effects of 2 serotonin reuptake inhibitor augmentation strategies, risperidone or cognitive-behavioral therapy consisting of exposure and ritual prevention, vs pill placebo in adults with obsessive-compulsive disorder. See related editorial by Ressler.