Submitted for Publication: November 9, 2010; final revision received January 31, 2011; accepted March 21, 2011.
Financial Disclosure: Dr Czermak has received salary support from the Max Kade Foundation, Inc. Dr Krystal has been a consultant to Aisling Capital LLC; AstraZeneca Pharmaceuticals; Brintnall& Nicolini, Inc; Easton Associates, LLC; Gilead Sciences, Inc; GlaxoSmithKline plc; Ortho-McNeil-Janssen Pharmaceuticals, Inc; Lundbeck Research USA, Inc; Merz Pharmaceuticals GmbH; MK Medical Communications; Pfizer, Inc; F. Hoffmann–La Roche Ltd; SK Holdings Co Ltd; Takeda Pharmaceutical Company Limited; Teva Pharmaceutical Industries Ltd; and Transcept Pharmaceuticals, Inc; and has the following patents and inventions: with Seibyl JP, Krystal JH, and Charney DS, dopamine and noradrenergic reuptake inhibitors in the treatment of schizophrenia, patent No. 5 447 948, September 5, 1995; and a coinventor on a filed patent application by Yale University related to targeting the glutamatergic system for the treatment of neuropsychiatric disorders (Patent Application No. PCTWO06108055A1).
Funding/Support: This study was supported by awards R21 MH081103 (through the American Recovery and Reinvestment Act), R21 MH085627, and RL1 AA017540 from the National Institutes of Health; the Department of Veterans Affairs (VA) through its support of the Clinical Neurosciences Division of the VA National Center for PTSD; a VA merit review grant; and a Brain and Behavior Research Foundation (formerly the National Alliance for Research on Schizophrenia and Depression) 2007 Independent Investigator Award (Dr Neumeister). Dr Murrough receives research support from the Brain and Behavior Research Foundation and salary support through a Mount Sinai School of Medicine research fellowship funded with an educational grant from AstraZeneca Pharmaceuticals.
Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Mental Health of the National Institutes of Health, the VA, or the Brain and Behavior Research Foundation.
Previous Presentation: This study was presented in part at the Society of Biological Psychiatry 66th Annual Meeting; May 13, 2011; San Francisco, California.
Additional Contributions: We thank the staff of the Yale PET Center; Sue Kasserman, RN, for her help in recruitment and patient care; Brenda Breault, RN, BSN, for her contributions to patient care during the scans via PET; and the Yale-Pfizer Bioimaging Alliance for support in the development of [11C]P943.