Submitted for Publication: April 27, 2011; final revision received May 31, 2011; accepted June 1, 2011.
Financial Disclosure: The University of California, Los Angeles, owns US patent No. 6 274 119, titled“Methods for Labelingβ-Amyloid Plaques and Neurofibrillary Tangles,” that uses the approach outlined in this article. Drs Small and Barrio are among the inventors of this work, have received royalties for it, and will receive royalties on future sales. Dr Small reports having served as a consultant and/or having received lecture fees from Brainstorming Co; Dakim, Inc; Eisai Co, Ltd; Forest Pharmaceuticals, Inc; Medivation, Inc; Myriad Genetics, Inc; Novartis AG; Ortho-McNeil-Janssen Pharmaceuticals; Pfizer Inc; Radica Games Limited; and Siemens Medical Solutions USA, Inc. Dr Small also reports having received stock options from Dakim, Inc. Dr Barrio reports having served as a consultant for and having received lecture fees from Nihon Medi-Physics Co, Ltd; Bristol-Meyer Squibb; PETNET Solutions; Noscira S.A.; and Siemens Medical Solutions USA, Inc. He also gratefully acknowledges the support of the Elizabeth and Thomas Plott Chair Endowment in Gerontology at the David Geffen School of Medicine at the University of California, Los Angeles.
Funding/Support: This study was supported by National Institutes of Health grants 5R21MH080258, P01-AG024831, AG13308, P50AG16570, MH/AG58156, MH52453, AG10123, and M01-RR00865; the United States Department of Energy (contract DE-FC03-87-ER60615); the General Clinical Research Centers; the Fran and Ray Stark Foundation Fund for Alzheimer's Disease Research; the McMahan Family Charitable Foundation; the Ahmanson Foundation; the Parlow-Solomon Professorship at the David Geffen School of Medicine at the University of California, Los Angeles; the Elizabeth and Thomas Plott Chair Endowment in Gerontology; and the Judith Olenick Elgart Fund for Research on Brain Aging. No company provided support of any kind for this study.
Additional Contributions: Emma Rhodes, MA, provided assistance in the final editing and technical assistance in preparation of the manuscript.