Submitted for Publication: June 10, 2011; final revision received August 19, 2011 accepted September 11, 2011.
Published Online: November 7, 2011. doi:10.1001/archgenpsychiatry.2011.151
Author Contributions: Drs Shulha and Cheung contributed equally. Drs Akbarian and Weng are co–senior authors, had full access to all of the data in the study, and take responsibility for the integrity of the data and the accuracy of the data analysis.
Financial Disclosure: None reported.
Funding/Support: This work was supported by Autism Speaks, the International Mental Health Research Organization, the National Alliance for Research on Schizophrenia and Depression, and grants 5 R01MH071476 and RC1MH088047 from the National Institute of Mental Health (Dr Akbarian). Dr Weng was supported in part by grant DBI-0850008 from the National Science Foundation.
Role of the Sponsors: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.
Additional Information: This article is dedicated to the memory of Edward G. Jones, MD, PhD.
Additional Contributions: Ron Zielke, MD, and staff from the Brain and Tissue Bank of the University of Maryland, Francine M. Benes, MD, PhD, and staff from the Harvard Brain Tissue Resource Center and the Autism Tissue Program (under director Jane Pickett, MD), William E. Bunney Jr, MD, from the University of California, Irvine, and Edward G. Jones, MD, PhD, from the University of California, Davis, supplied some of the postmortem brain tissue used in this study, and Ellen Kittler, PhD, and Maria Zapp, PhD, from the University of Massachusetts Medical School Deep Sequencing Core, Richard Konz, PhD, and staff from the University of Massachusetts Medical School Flow Cytometry Core, and Eric Morrow, PhD, MD, provided helpful discussions.