Submitted for Publication: May 9, 2012; final revision received July 31, 2012; accepted August 25, 2012.
Published Online: February 27, 2013. doi:10.1001/jamapsychiatry.2013.684
Author Contributions: Drs Ross and Grigoriadis had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Conflict of Interest Disclosures: Dr Grigoriadis has a New Investigator Award in Women's Health Research from the Canadian Institutes of Health Research (CIHR) in partnership with the Ontario Women's Health Council, Award NOW-88207 and has received honoraria as a consultant, member of an advisory committee, or for lectures during the past 5 years from Wyeth Pharmaceuticals, GlaxoSmithKline, Pfizer, Servier, Eli Lilly Canada, and Lundbeck, as well as research grant support from the CIHR, Ontario Ministry of Health, Ontario Mental Health Foundation, and the C. R. Younger Foundation. Dr Rehm has received an unrestricted educational grant from Lundbeck to support work on alcohol dependence. Dr Koren has received research support from Wyeth Inc and Janssen-Ortho Inc; research support from Duchesnay Inc, Novartis Pharmaceuticals Corporation, Apotex Inc, and Pfizer Laboratories; as well as honoraria for various lectures. Dr Steiner has received honoraria as a consultant for Wyeth Pharmaceuticals, Bayer Schering Pharmaceuticals, AstraZeneca, Azevan Pharmaceuticals, and Servier; grant/research support from Wyeth, GlaxoSmithKline, AstraZeneca, Lundbeck, and the CIHR; and honoraria from Azevan Pharmaceuticals, AstraZeneca, Ortho-McNeil, the Society for Women's Health Research, and AstraZeneca.
Funding/Support: This study was funded by Research Syntheses grant KRS-83127 from the CIHR, and grant 2008-005 from the Ontario Ministry of Health and Long-term Care through the Drug Innovation Fund. Dr Ross is supported by a New Investigator Award from CIHR and the Ontario Women's Health Council, Award NOW-84656. In addition, support to the Centre for Addiction and Mental Health for salary of scientists and infrastructure has been provided by the Ontario Ministry of Health and Long-term Care.
Disclaimer: The views expressed here do not necessarily reflect those of the Ontario Ministry of Health and Long-term Care.
Previous Presentations: This work has been presented at the Canadian Psychiatric Association Convention; October 13-15, 2011; Vancouver, British Columbia, Canada; the Canadian Institutes for Health Research, Innovations in Gender, Sex, and Health Research Conference; November 22-23, 2010; Toronto, Ontario, Canada; the Canadian Psychiatric Association Convention; September 23-26, 2010; Toronto; the 36th Annual Meeting of the North American Society for Psychosocial Obstetrics and Gynecology; February 10-13, 2010; Richmond, Virginia; The Organization for the Study of Sex Differences Third Annual Meeting; June 4-6, 2009; Toronto; the 35th Annual Meeting of the North American Society for Psychosocial Obstetrics and Gynecology; February 4-7, 2009; New Haven, Connecticut; and the Canadian College of Neuropsychopharmacology Annual Meeting; June 6-9, 2008; Toronto.
Additional Contributions: The Advisory Committee members provided valuable input and lent their expertise to this project: Jennifer Blake, MD; Hiltrud Dawson, RN; Michael Dunn, MD; Adrienne Einarson, RN; Alicja Fishell, MD; Jasmine Gandhi, MD; Jan Kasperski, RN,MHSc; Sidney Kennedy, MD; Diane Meschino, MD; Irena Nulman, MD, PhD; Sagar Parikh, MD; Paula Ravitz, MD; Sarah Romans, MD; Simone Vigod, MD; and Karen Wade, RN, MScN. Lindsay Witton, MSW; Maura O’Keefe, MSW; and Svetlana Emelianova, MD, provided feedback during many research meetings. Sheila Lacroix, MLS, and Ani Orchanian-Cheff, MISt, devised search strategies and completed the literature search. Alex Kiss, PhD, performed preliminary meta-analyses. Allison Eady, BA; Jenna McKay, BA; and Kimberly Radford, BA, assisted with data extraction and quality assessment processes.