Submitted for Publication: July 16, 2012; final revision received September 21, 2012; accepted October 29, 2012.
Published Online: April 3, 2013. doi:10.1001/jamapsychiatry.2013.1195
Author Contributions: Drs Horwitz and Tsuang jointly directed this work, had full access to all the data in the study, and take responsibility for the integrity of the data and the accuracy of the data analysis.
Conflict of Interest Disclosures: Dr Eichler is on the scientific advisory boards for Pacific Biosciences Inc, SynapDx Corp, and DNAnexus Inc.
Funding/Support: This work was supported by the National Institutes of Health, US Department of Veterans Affairs, and the Brain and Behavior Research Foundation. Additional material is based on work supported by the Office of Research and Development Medical Research Service, Department of Veterans Affairs. Specific funding was provided by a National Alliance for Research on Schizophrenia and Depression Independent Investigator Award (Dr Tsuang), Consortium on the Genetics of Schizophrenia grant R01MH065558 (Dr Tsuang), VA Merit Review (Dr Tsuang), and National Institute of Health, National Institute of General Medical Sciences grant T32GM007454 (Dr Timms).
Additional Contributions: We thank the subjects and their families who participated in this study and who donated blood samples to the National Institute of Mental Health for genetic research purposes. We thank Eva Crist for technical assistance and Zoran Brkanac, MD, and Wendy Raskind, MD, PhD, for input in initial pedigree selection. Data and biomaterials were collected in 3 projects participating in the National Institute of Mental Health Schizophrenia Genetics Initiative: from 1991 to 1997, principal investigator and coinvestigators were Harvard University (grant U01MH46318): Ming T. Tsuang, MD, PhD, DSc, Stephen Faraone, PhD, and John Pepple, PhD; Washington University, St Louis, Missouri (grant U01MH46276): C. Robert Cloninger, MD, Theodore Reich, MD, and Dragan Svrakic, MD; and Columbia University (grant U01MH46289): Charles Kaufmann, MD, Dolores Malaspina, MD, MSPH, and Jill Harkavy Friedman, PhD.