Submitted for Publication: July 20, 2012; final revision received December 21, 2012; accepted December 21, 2012.
Published Online: August 7, 2013. doi:10.1001/jamapsychiatry.2013.187.
Study concept and design: Magistretti, Eap.
Acquisition of data: Choong, Cardinaux, Vandenberghe, Bondolfi, Etter, Holzer, von Gunten, Preisig, Vollenweider, Waeber, Conus.
Analysis and interpretation of data: Choong, Quteineh, Gholam-Rezaee, Dobrinas, Vollenweider, Beckmann, Pralong, Kutalik, Bochud.
Drafting of the manuscript: Choong, Quteineh, Vandenberghe, Bochud.
Critical revision of the manuscript for important intellectual content: Quteineh, Cardinaux, Gholam-Rezaee, Dobrinas, Bondolfi, Etter, Holzer, Magistretti, von Gunten, Preisig, Vollenweider, Beckmann, Pralong, Waeber, Kutalik, Conus, Bochud, Eap.
Statistical analysis: Choong, Quteineh, Gholam-Rezaee, Kutalik, Bochud.
Obtained funding: Preisig, Vollenweider, Waeber, Eap.
Administrative, technical, and material support: Choong,Vandenberghe, Bondolfi, Magistretti, Preisig, Pralong.
Study supervision: Eap.
Conflict of Interest Disclosures: Drs Vollenweider and Waeber received an unrestricted grant from GlaxoSmithKline to build the CoLaus study. The CoLaus study received financial contributions from GlaxoSmithKline. Dr Eap received honoraria for conferences or teaching continuing medical education courses from Advisis, AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Essex Chemie, GlaxoSmithKline, Janssen-Cilag, Lundbeck, Merck Sharp & Dohme, Novo Nordisk, Organon, Sandoz, and Vifor Pharma. Dr von Gunten received honoraria for a conference or workshop participation from Vifor Pharma and Bayer Schering. Dr Preisig received honoraria for conferences or teaching continuing medical education courses from AstraZeneca, Lundbeck, Servier SA, and swissprofessionalmedia AG. No other author reported disclosures.
Funding/Support: This work was funded in part by Swiss National Research Foundation grants 120686 (Drs Eap and Conus) and 135692 (Dr Cardinaux) and by the National Center of Competence in Research “SYNAPSY—The Synaptic Bases of Mental Diseases” financed by Swiss National Science Foundation grant 51AU40_125759. Dr Bochud is supported by the Swiss School of Public Health Plus. The CoLaus study received financial contributions from the Faculty of Biology and Medicine of University of Lausanne and Swiss National Science Foundation grants 33CSCO-122661, 3200BO-111361/2, 3100AO-116323/1, and 310000-112552. Development of the Quanto program was supported in part by National Institute of Environmental Health Sciences grants ES10421 and 5P30ESO7048-03 and National Cancer Institute grant CA52862.
Group Information: The ODEX team members are Linda C. McCarthy, Judong Shen, Matthew R. Nelson, Peter M. Woollard, Keith L. Nangle, Kijoung Song, Dawn M. Waterworth, and John C. Whittaker (GlaxoSmithKline members); Inês Barroso, Eleftheria Zeggini, Aaron Day-Williams, Margarida C. Lopes, Lorraine Southam, Ioanna Tachmazidou, Jennifer Asimit, Eleanor Wheeler, Carol E. Scott, Alison J. Coffey, Chris Tyler-Smith, Yali Xue, Yuan Chen, Jillian Durham, and Felicity Payne (also Sarah Hunt, who has now left the institute and is working at the European Bioinformatics Institute) (the Wellcome Trust Sanger Institute members); and Jacques S. Beckmann, Sven Bergmann, Murielle Bochud, Zoltan Kutalik, Pedro Marques-Vidal, Vincent Mooser, Peter Vollenweider, and Gérard Waeber (CoLaus members [alphabetical order]).
Additional Contributions: We thank Severine Crettol-Wavre, PharmD, PhD, and Vincent Mooser, MD, for scientific support, Christian Brogli and Veronique Hodel for logistical assistance, Elisabeth Retamales for bibliographical help, and Anne-Catherine Aubert, Murielle Brocard, Nathalie Cochard, Myriam Delessert, Astrid Kottelat-Vullioud, Marlyse Brawand, Kerry Powell Golay, Sylvie Jaquet, and Michele Jonzier for sample analysis. We are also grateful for the access to exome sequence data from the CoLaus cohort, which was sequenced as part of a partnership between the Wellcome Trust Sanger Institute, the CoLaus principal investigators, and the Quantitative Sciences Department of GlaxoSmithKline. We thank the GIANT consortium for access to their BMI association results in 123 807 individuals. James Gauderman, PhD, author of the Quanto program, thanks Robert Elston, PhD, for kind permission to use the S.A.G.E. routine MAXFUN for function maximization and Joshua Millstein for providing the numerical integration routines.