Submitted for Publication: July 31, 2012; final revision received January 18, 2013; accepted February 14, 2013.
Published Online: September 4, 2013. doi:10.1001/jamapsychiatry.2013.1969.
Study concept and design: Jarrett, Thase.
Acquisition of data: Jarrett, Gershenfeld, Friedman, Thase.
Analysis and interpretation of data: All authors.
Drafting of the manuscript: Jarrett, Minhajuddin, Thase.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Minhajuddin
Obtained funding: Jarrett, Thase.
Administrative, technical, or material support: All authors.
Study supervision: Jarrett, Gershenfeld, Friedman, Thase.
Conflict of Interest Disclosures: Dr Jarrett’s medical center collects the payments from the cognitive therapy she personally provides to patients. Dr Jarrett is a paid consultant to the National Institute of Mental Health. Drs Minhajuddin and Gershenfeld report no related financial interests. Dr Friedman has received grant support from the National Institute of Mental Health and Agency for Healthcare Research and Quality. He has served as an expert forensic psychiatrist for Thompson Rhodes & Cowie PC and Berger and Zavesky Co LPP. He receives royalties from Springer. He has been a member of speaker bureaus or advisory boards for AstraZeneca, Eli Lilly, GlaxoSmithKline, Pfizer, Weth-Ayerst, and Pamlab. He has received grant or research support from Aspect Medical Systems, Indevus, AstraZeneca, Bristol-Myers Squibb, Pfizer, Sanofi-Aventis, Wyeth-Ayerst, Cyberonics, Novartis, Northstar, and Medtronic. During the past 5 years, Dr Thase has consulted with, served on advisory boards for, or received honoraria for talks from Alkermes, Allergan, AstraZeneca, Bristol-Myers Squibb, Eli Lilly and Co, Forest Laboratories, GlaxoSmithKline, Janssen Pharmaceutica, Lundbeck, MedAvante Inc, Merck, Neuronetics Inc, Novartis, Otsuka, Pamlab, Pfizer Pharmaceuticals, Pharmaneuroboost, Shire US Inc, Sunovion, Takeda, Teva, and Transcept Pharmaceuticals. And he has received grant support from Alkermes, AstraZeneca, Eli Lilly and Co, Forest Laboratories, GlaxoSmithKline, Neosync, Otsuka, Pharmaneuroboost, and Roche, in addition to funding from the National Institute of Mental Health and the Agency for Healthcare Research and Quality. He has equity holdings for MedAvante Inc and has received royalties from American Psychiatric Publishing Inc (APPI), Guilford Publications, Herald House, and W. W. Norton & Co Inc. Two books currently promoted by the APPI specifically pertain to cognitive therapy. Dr Thase also discloses that his spouse is an employee of Peloton Advantage, which does business with several pharmaceutical companies that market medications used to treat depression. No other disclosures were reported.
Funding/Support: This study was supported by grants K24 MH001571, R01 MH058397, and R01 MH069619 (Dr Jarrett) and by R01 MH058356 and R01 MH069618 (Dr Thase) from the National Institute of Mental Health. We acknowledge the unrestricted support of Eli Lilly and Co, which provided fluoxetine and matched pill placebo for the first 6 years of the study. Thereafter, study materials were purchased and prepared to appear identical for both sites by the pharmacy at The University of Texas Southwestern Medical Center.
Role of the Sponsor: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Mental Health or the National Institutes of Health. The National Institute of Mental Health had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Additional Contributions: We are grateful to our patients, research teams, and colleagues at The University of Texas Southwestern Medical Center, the University of Pittsburgh, and the University of Pennsylvania who made this trial possible and were named earlier.26 We also appreciate the collaboration of Jeffrey Vittengl, PhD (Truman State University), who helped to demonstrate that planned survival analysis and secondary frailty analysis produced equivalent results.
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