Submitted for Publication: December 7, 2012; final revision received February 13, 2013; accepted February 16, 2013.
Published Online: September 11, 2013. doi:10.1001/jamapsychiatry.2013.1932.
Study concept and design: Simpson, Foa, Liebowitz, Huppert, Marcus, Campeas.
Acquisition of data: Simpson, Huppert, Cahill, Maher, McLean, Bender, Williams, Vermes, Van Meter, Rodriguez, Powers, Pinto, Imms, Hahn, Campeas.
Analysis and interpretation of data: Simpson, Foa, Liebowitz, Huppert, Cahill, Marcus, Weaver, Van Meter.
Drafting of the manuscript: Simpson, Foa, Marcus.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Simpson, Marcus, Weaver, Van Meter.
Obtained funding: Simpson, Foa, Liebowitz.
Administrative, technical, or material support: Simpson, Foa, Maher, McLean, Bender, Williams, Vermes, Van Meter, Rodriguez, Powers, Imms, Hahn.
Study supervision: Simpson, Foa, Huppert, Cahill, Maher, McLean, Bender, Williams, Powers, Pinto, Imms, Campeas.
Conflict of Interest Disclosures: During this study, in addition to medication at no cost from Janssen Scientific Affairs LLC, Dr Simpson received research funds from Transcept Pharmaceuticals (2011-2013) and Neuropharm Ltd (2009), served on a scientific advisory board for Pfizer (for Lyrica, 2009-2010) and Jazz Pharmaceuticals (for Luvox CR [controlled release], 2007-2008), and received royalties from Cambridge University Press and UpToDate Inc. Dr Foa was a consultant to Jazz Pharmaceuticals (for Acetelion), and she receives royalties from Bantam and Oxford University Press for book sales, including a manual of cognitive-behavioral therapy for OCD. Dr Liebowitz received research funds from pharmaceutical companies (Abbott, Allergan, AstraZeneca, Avera, Forest, Cephalon, Endo, Gruenthal, GlaxoSmithKline, Horizon, Indevus, Jazz Pharmaceuticals, Johnson & Johnson, Lilly, Lundbeck, MAP, Novartis, Ortho-McNeil, Pfizer, PGX Health, Purdue Pharma, Sepracor, Takeda, Tikvah, and Wyeth), consulted (to AstraZeneca, Avera, Eisai, Lilly, Otsuka, Pfizer, Pherin Pharmaceutical, Takeda, Tikvah, and Wyeth), presented talks or posters (for Pherin Pharmaceutical, Pfizer, and Wyeth), has equity ownership in Pherin Pharmaceutical, ChiMatrix LLC (ended 2011), and the Liebowitz Social Anxiety Scale, and has licensing software for the Liebowitz Social Anxiety Scale for Avera, Endo, GlaxoSmithKline, Indevus, Lilly, Pfizer, Servier, and Tikvah. Dr Hahn received research funds from Pfizer, GlaxoSmithKline, and AstraZeneca. No other disclosures were reported.
Funding/Support: This study was funded by National Institute of Mental Health grants R01 MH045436 (Dr Simpson) and R01 MH45404 (Dr Foa). Medication was provided at no cost by Janssen Scientific Affairs LLC.
Role of the Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Information: This study was conducted at 2 sites: the Anxiety Disorders Clinic at Columbia University/the New York State Psychiatric Institute (1051 Riverside Dr, Unit 69, New York, NY 10032) and the Center for the Treatment and Study of Anxiety in the Department of Psychiatry, University of Pennsylvania (3600 Market St, Philadelphia, PA 19104).
Additional Contributions: We thank staff of the Anxiety Disorders Clinic and Center for the Treatment and Study of Anxiety for help conducting this trial, including the expert research assistance of Samantha Farris, BA, Jessica McCarthy, BA, Rena Staub, BA, Liane Hunter, BA, and Josephine Curry, BA. We also thank John Markowitz, MD, and Franklin Schneier, MD, for commenting on a prior draft of the manuscript. We thank the study subjects for participating.