Submitted for Publication: August 23, 2012; final revision received February 26, 2013; accepted February 27, 2013.
Published Online: September 11, 2013. doi:10.1001/jamapsychiatry.2013.1957.
Study concept and design: Judd, Schettler, Coryell, Akiskal.
Acquisition of data: Judd, Schettler, Coryell.
Analysis and interpretation of data: Judd, Schettler, Akiskal, Fiedorowicz.
Drafting of the manuscript: Judd, Schettler.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Judd, Schettler.
Obtained funding: Coryell.
Administrative, technical, or material support: Judd, Fiedorowicz.
Study supervision: Akiskal.
Conflict of Interest Disclosures: Dr Akiskal has received compensation for presentations from the López-Ibor, Lilly, and Lundbeck foundations and from AstraZeneca, Bristol-Myers Squibb and Otsuka, GlaxoSmithKline, Merck, and Sanofi-Synthélabo. Dr Schettler has provided statistical consulting services to BrainCells Inc, Methylation Sciences Inc, Novartis BioVentures, and Clintara LLC. No other disclosures were reported.
Funding/Support: The initial funding source for the database used in this study was the NIMH.
Role of the Sponsors: This study has been approved for submission by the Publications Committee of the NIMH Collaborative Depression Study.
Additional Contributions: This study was conducted with the participation of the following investigators: M. B. Keller, MD (Chairperson, Providence, Rhode Island); W. Coryell, MD (co-chairperson, Iowa City, Iowa); T. I. Mueller, MD, and D. A. Solomon, MD (Providence, Rhode Island); J. Fawcett, MD, and W. A. Scheftner, MD (Chicago, Illinois); J. Haley (Iowa City, Iowa); J. Endicott, PhD, and J. Loth, MSW (New York, New York); and J. Rice, PhD, and T. Reich, MD (deceased) (St Louis, Missouri). Other contributors include H. S. Akiskal, MD, N. C. Andreasen, MD, PhD, P. J. Clayton, MD, J. Croughan, MD, R. M. A. Hirschfeld, MD, L. Judd, MD, M. M. Katz, PhD, P. W. Lavori, PhD, J. D. Maser, PhD, M. T. Shea, PhD, R. L. Spitzer, MD, and M. A. Young, PhD, as well as the following deceased contributors: G. L. Klerman, MD, E. Robins, MD, R. W. Shapiro, MD, G. Winokur, MD, and A. C. Leon, PhD.