Submitted for Publication: October 10, 2012; final revision received March 18, 2013; accepted March 21, 2013.
Published Online: October 2, 2013. doi:10.1001/jamapsychiatry.2013.2159.
Study concept and design: Lane, Green, Chen, Tsai.
Acquisition of data: Lane, Lin, Huang, Tun.
Analysis and interpretation of data: Lane, Green, Hellemann, Huang, Chang, Tsai.
Drafting of the manuscript: Lane, Green, Tsai.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Lane, Hellemann, Huang, Tun, Chang, Tsai.
Obtained funding: Lane.
Administrative, technical, and material support: Lane, Lin, Green, Huang.
Study supervision: Lane, Tsai.
Conflict of Interest Disclosures: Sodium benzoate treatment is claimed in patent applications US 0189818 and WO 2010/085452, for which Dr Tsai is the inventor. Dr Tsai became shareholder of SyneuRx International Corp, which develops benzoate and other d-amino acid oxidase inhibitors for the treatment of central nervous system disorders after the study and analysis were completed. No other disclosures were reported.
Funding/Support: This work was supported in part by grants NSC-97-2314-B-039-006-MY3, NSC-99-2314-B-280-001-MY3, NSC-99-2811-B-039-005, NSC-100-2627-B-039-001, NSC-101-2314-B-039-030-MY3, and NSC-101-2627-B-039-001 from the National Science Council of Taiwan, grant NHRI-EX-101-9904NI from the National Health Research Institutes of Taiwan, grant DOH102-TD-B-111-004 from the Taiwan Department of Health Clinical Trial and Research Center of Excellence, and grants CMU 101-AWARD-13, DMR-99-153, and DMR-99-117 from the China Medical University Hospital.
Role of the Sponsor: The sponsors were not involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Additional Contributions: The statistical analysis was performed by Dr Chang.