Editorial |

Making Progress With Magnetic Resonance Spectroscopy

Dost Öngür, MD, PhD1
[+] Author Affiliations
1Harvard Medical School, McLean Hospital, Belmont, Massachusetts
JAMA Psychiatry. 2013;70(12):1265-1266. doi:10.1001/jamapsychiatry.2013.2615.
Text Size: A A A
Published online


Leading neuroimaging researchers have joked that magnetic resonance spectroscopy (MRS) is a technique of the future and always will be. This skepticism is often well placed because the validation and replication of interesting MRS findings are less frequent than those using other brain imaging modalities. There are multiple reasons for this circumstance: the intrinsic MRS signal to noise ratio is low compared with structural and functional magnetic resonance imaging; specialized magnetic resonance imaging hardware and sequences are required for many MRS experiments, making widespread adoption and standardization difficult; and because MRS yields data on multiple metabolites, it is possible to report secondary findings even if the a priori hypothesis is not confirmed. On the other hand, MRS offers a unique window on brain function, one that is relevant for cellular processes implicated in the pathophysiology of psychiatric disorders. Therefore, the field of psychiatric neuroimaging has paid an unfortunate price for failure to make progress in this domain.

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Topics
PubMed Articles