Submitted for Publication: November 13, 2012; final revision received February 18, 2013; accepted March 29, 2013.
Published Online: October 16, 2013. doi:10.1001/jamapsychiatry.2013.2224.
Study concept and design: Wilson, Nag, Boyle, Arnold, Bennett.
Acquisition of data: Nag, Hizel, Schneider, Bennett.
Analysis and interpretation of data: Wilson, Nag, Boyle, Yu, Buchman, Shah, Schneider, Arnold, Bennett.
Drafting of the manuscript: Wilson, Nag, Hizel, Schneider, Arnold.
Critical revision of the manuscript for important intellectual content: Wilson, Nag, Boyle, Yu, Buchman, Shah, Schneider, Arnold, Bennett.
Statistical analysis: Yu.
Obtained funding: Wilson, Buchman, Bennett.
Administrative, technical, and material support: Nag, Boyle, Hizel, Schneider, Arnold, Bennett.
Study supervision: Schneider, Bennett.
Conflict of Interest Disclosures: None reported.
Funding/Support: This research was supported by grants R01AG17917, R01AG15819, R01AG24871, R01AG34374, R01AG33678, R01AG43379, and R01NS78009 from the National Institutes of Health and by the Illinois Department of Public Health.
Role of the Sponsor: The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: Traci Colvin, MPH, and Karen Skish, MS, assisted with study coordination; John Gibbons, MS, and Greg Klein, MS, contributed to data management; and Wenqing Fan, MS, provided statistical programming. We thank the neuropathologic laboratory of the Rush Memory and Aging Project and the many Illinois residents for participating in the project.