Submitted for Publication: September 27, 2012; final revision received April 10, 2013; accepted May 6, 2013.
Published Online: October 30, 2013. doi:10.1001/jamapsychiatry.2013.2430.
Study concept and design: All authors.
Acquisition of data: Johnstone, Peterson, Kolden.
Analysis and interpretation of data: Heller, Johnstone, Kolden, Kalin, Davidson.
Drafting of the manuscript: Heller, Kolden, Davidson.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Heller, Davidson.
Obtained funding: Kalin.
Administrative, technical, or material support: All authors.
Study supervision: Johnstone, Kolden, Kalin, Davidson.
Conflict of Interest Disclosures: Dr Kalin has disclosed that he received grant support from APIRE/Janssen Resident Psychiatric Mentor Grant, the National Institute for Mental Health, and the Stanley Medical Research Institute. He serves on the scientific advisory boards of AstraZeneca, Bristol-Meyers Squibb, CeNeRx BioPharma, Centocor Ortho Biotech, Corcept Therapeutics, Cyberonics, Double Helix, Eli Lilly, Forest Laboratories, General Electric Corp, Jazz Pharmaceuticals, Medivation, Neurocrine Biosciences, Neuronetics, Neuronetics LLC, Otsuka American Pharmaceuticals, Sanofi Syntholabs, and Wyeth Pharmaceuticals. He is a stockholder and maintains equity options in CeNeRx BioPharma and Corcept Therapeutics. He is the owner of Promoter Neurosciences LLC and owns the following patents: promoter sequences for corticotropin-releasing factor CRF2α and method of identifying agents that alter the activity of the promoter sequences (US patent 7071323 issued on July 4, 2006; US patent 7531356 issue on May 12, 2009); promoter sequences for urocortin II and the use thereof (US patent 7087385 issued on August 8, 2006); and promoter sequences for corticotropin-releasing factor binding protein and use thereof (US patent 7122650 issued on October 17, 2006). No other disclosures were reported.
Funding/Support: This study was supported by National Institutes of Health grants P50 MH069315, P50-MH084051, and R01 MH043454 to Dr Davidson; a Wyeth-Ayerst Pharmaceuticals grant to Dr Kalin; and grants from the Fetzer Institute, the John Templeton Foundation, the John W. Kluge Foundation, and the Impact Foundation.
Role of the Sponsor: The funding agencies had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.