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Comment & Response |

A Leap of Faith in Antidepressant Treatment?

Barbara Mintzes, PhD1
[+] Author Affiliations
1School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada
JAMA Psychiatry. 2013;70(12):1373. doi:10.1001/jamapsychiatry.2013.2114.
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To the Editor The Ross et al systematic review1 of pregnancy and delivery outcomes following exposure to antidepressants in pregnancy found only harm, not benefit, associated with antidepressant exposure. Some effects were attenuated after controlling for depression in pregnancy; in other cases, the association with a negative health outcome remained as strong.

Ross et al describe this harm as being of small magnitude and highlight the need to weigh these adverse events against the harm from untreated depression. This recommendation is puzzling, given that their systematic review fails to demonstrate that antidepressant treatment mitigates any harm associated with depression.


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June 1, 2014
Lori E. Ross, PhD; Sophie Grigoriadis, MD, MA, PhD, FRCPC
1Centre for Addiction and Mental Health, Toronto, Ontario, Canada
2Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
JAMA Psychiatry. 2014;71(6):716-717. doi:10.1001/jamapsychiatry.2014.59.
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