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Comment & Response |

Antidepressant Medication and Spontaneous Abortion “No Significant Association”? Clinically Significant Association!

Catalin Tufanaru, MD, MPH1; Jon Jureidini, MBBS, PhD2
[+] Author Affiliations
1The Joanna Briggs Institute, School of Translational Health Science, Faculty of Health Sciences, The University of Adelaide, Adelaide, South Australia, Australia
2Department of Psychological Medicine, Women’s and Children’s Hospital, North Adelaide, South Australia, Australia
JAMA Psychiatry. 2013;70(12):1373-1374. doi:10.1001/jamapsychiatry.2013.2274.
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To the Editor Ross et al reported “no significant association between antidepressant medication exposure and spontaneous abortion (odds ratio [OR], 1.47; 95% CI, 0.99 to 2.17; P = .055)” (italics, our emphasis).1(p436) Confidence intervals provide inferential evidence about the range of plausible values for the population parameter of interest.2,3 A simple examination of the values covered by the reported 95% CI from 0.99 to 2.17 suffices to show that an association between the exposure to antidepressant medication and spontaneous abortion is likely and that results are nonnegligible from a clinical perspective. Results are not statistically significant but the differences are of clinical interest.


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June 1, 2014
Lori E. Ross, PhD; Sophie Grigoriadis, MD, MA, PhD, FRCPC
1Centre for Addiction and Mental Health, Toronto, Ontario, Canada
2Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
JAMA Psychiatry. 2014;71(6):716-717. doi:10.1001/jamapsychiatry.2014.59.
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